The active ingredients amoxycillin (as amoksitsillinatrigidrata) 400 mg; Clavulanic acid (as potassium clavulanate) 57 mg
Other ingredients: Xanthan gum, aspartame, colloidal anhydrous silica, magnesium stearate, crospovidone, natriyakroskarmelloza, sodium benzoate, flavor, strawberry, silicon dioksidbezvodny, as UK specialists say.
The powder is white or almost white color with yellow particles, with a characteristic odor. Prepared suspension white or nearly white. On standing, the precipitate formed slowly white or nearly white.
Megamentin 1000 is a combined antibiotic containing amoxycillin and clavulanic acid, with a broad spectrum bactericidal action, resistant to beta-lactamase.
Amoxicillin - a semi-synthetic broad-spectrum antibiotic active against many gram-positive and gram-negative microorganisms. Amoxicillin is destroyed by deystviembeta-lactamases, and has no effect on the microorganisms that produce etoferment. Its mechanism of action is to inhibit cell wall biosintezamukopeptidov.
Clavulanic acid - a beta-laktamat structurally related to the penicillins, which possesses the ability to inactivate a wide spektrbeta-lactamases. Beta-lactamases are produced by many Gram-positive bacteria igramotritsatelnymi. The action of beta-lactamases can lead krazrusheniyu some antibacterial drugs even before they vozdeystviyana pathogens. Clavulanic acid blocks the action of enzymes, vosstanavlivayachuvstvitelnost bacteria to amoxicillin. In particular, it has vysokoyaktivnostyu plasmid against beta-lactamases, which often svyazanalekarstvennaya resistance, but is less effective against hromosomnyhbeta lactamase-1 type.
The presence of clavulanic acid in the Megamentin 1000 (UK) amoxicillin protects against the damaging action of beta-lactamases and extends its spectrum of antibacterial activity with the inclusion of micro-organisms normally resistant to other cephalosporins and penicillins.