Experts from the UK claim: It normalizes the terminal differentiation of the cells, inhibits the proliferation of the epithelium of the sebaceous glands, the formation of detritus, facilitates its evacuation. It reduces the production and facilitates the secretion of sebum.
Application of Isotretinoin (UK)
For oral and rectal administration: severe forms of acne (nodular or cystic, conglobata, acne scarring risk); Acne is not amenable to other therapies.
For topical use: acne vulgaris, seborrheic dermatitis, rosacea, perioral dermatitis.
Side effects of substance Isotretinoin
Scientists from the UK detected:
From the nervous system and sensory organs: excessive fatigue, headache, increased intracranial pressure (cerebral pseudotumor: headache, nausea, vomiting, blurred vision, swelling of the optic nerve), seizures, xerophthalmia, individual cases of violations of visual acuity, photophobia, violation of dark adaptation (decrease in visual twilight vision); rarely - depression, psychosis, suicidal ideation, disturbance of color vision (goes after drug discontinuation), lenticular cataract, keratitis, blepharitis, conjunctivitis, eye irritation, optic neuritis; impaired hearing at certain frequencies of sound.
From the digestive tract: dryness of the oral mucosa, bleeding from the gums, inflammation of the gums, nausea, diarrhea, inflammatory bowel disease (colitis, ileitis), bleeding, pancreatitis (particularly with concomitant hypertriglyceridemia above 800mg / dl). Described rare cases of pancreatitis with fatal outcome, transient and reversible increases in liver transaminases and isolated cases of hepatitis (in many of these cases, the changes do not go beyond the limit of normal and return to the beginning levels during treatment, but there was a need to reduce the dose or stop the drug in some situations ).
From hemopoiesis system: anemia, decreased hematocrit, leukopenia, neutropenia, increase or decrease the number of platelets, ESR acceleration.