Exemever during a steroid cycle to prevent side effects that can cause flavoring steroids. It should be noted that the action Exemever is radically different from the usual action of Tamoxifen for many athletes from UK.
It is known that Tamoxifen has no effect on the aromatization process. It just begins to interact with the cellular estrogen receptors, preventing estrogen to join them and form a bond. Exemever same effect on the process of flavoring and suppresses it. Exemever structure is very similar to a naturally occurring steroid androstenedione. Exemever principle of action is that it binds irreversibly to active enzymes with hormones. As a result, hormones lose their activity. Exemever not have no estrogen without progestogen activity. But it is characterized by mild androgenic activity.
Representative steroidal aromatase third generation ingbitorov exemestane is that entering into covalent interaction with aromatase during the first cycle of oxidation leads to an effective selective irreversible inactivation of the enzyme reduces and estrogen synthesis in the body by 97%.
Like anastrazole and letrozole, it is well tolerated by patients. Produced for receiving per os in form of tablets of 25 mg, and the daily dose is in the treatment of metastatic breast cancer in postmenopausal women from UK.
Exemestane, which is approved in the UK and is used as a drug in the oncology first-line endocrine therapy for breast cancer after receiving Imre class of drugs so far in the clinical setting has not been studied. However, it found that with respect to the process of accumulation and the extent of aromatization of estrogens it has an activity higher than tamoxifen, but less high than anastrozole (AS TO comparative study, 2002).